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cialis side effects Y metabolized by CYP3A4. Studies have shown that drugs that inhibit CYP3A4 can increase tadalafil exposure (see PRECAUTIONS and DOSAGE AND ADMINISTRATION). Ketoconazole — Ketoconazole (400 mg daily) cialis side effects, a selective and potent inhibitor of CYP3A4 cialis side effects, increased tadalafil 20-mg single-dose exposure (AUC) by 312% and Cmax by 22% cialis side effects, relative to the values for tadalafil 20 mg alone. Ketoconazole (200 mg daily) increased tadalafil 10-mg single-dose exposure (AUC) by 107% and Cmax by 15% cialis side effects, relative to the values for tadalafil 10 mg alone. HIV Protease inhibitor — Ritonavir (200 mg twice daily) cialis side effects, an inhibitor of CYP3A4 cialis side effects, CYP2C9 cialis side effects, CYP2C19 cialis side effects, and CYP2D6 cialis side effects, increased tadalafil 20-mg single-dose exposure (AUC) by 124% with no change in Cmax cialis side effects, relative to the values for tadalafil 20 mg alone. Although specific interactions have not been studied cialis side effects, other HIV protease inhibitors would likely increase tadalafil exposure (see DOSAGE AND ADMINISTRATION). Based upon these results cialis side effects, in patients taking concomitant potent CYP3A4 inhibitors cialis side effects, the dose of CIALIS should not exceed 10 mg cialis side effects, and CIALIS should not be taken more frequently than once in every 72 hours (see DOSAGE AND ADMINISTRATION). Other cytochrome P450 inhibitors — Although specific interactions have not been studied cialis side effects, other CYP3A4 inhibitors cialis side effects, such as erythromycin cialis side effects, itraconazole cialis side effects, and grapefruit ju.
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