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Levitra vs cialis. Hin this class of drug. Giles Brindley and Drug Therapy for ED Modern drug therapy for ED was advanced enormously in 1983 when British physiologist Giles Brindley, Ph.D. dropped his trousers and demonstrated to a shocked AUA audience his phentolamine-induced erection. The drug Brindley injected into his penis was a non-specific vasodilator, an alpha-blocking agent, and the mechanism of action was clearly corporal smooth muscle relaxation. The effect that Brindley discovered, established the fundamentals for the later development of specific, safe, orally-effective drug therapies, ie, PDE-5 inhibitors. PDE Inhibition and Smooth Muscle Relaxation Phosphodiesterase (PDE) is an enzyme that causes breakdown of cyclic GMP, which is the direct intracellular mediator in the nitric oxide (nonadrenergic, noncholinergic) pathway. Discovery of this pathway led to a Nobel Prize in 1998 for the scientists responsible. The nitric oxide system causes relaxation of smooth muscle in blood vessel walls, levitra vs
 

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Ie, vasodilation, in various organ systems. The direct intracellular mediator of the nitric oxide pathway is cGMP. PDE catalyzes the degradation of cGMP. This pathway is active in numerous organ systems, and as of this writing, a number of different PDEs are known. The various PDEs differ in their physiologic roles and tissue distribution. Type 5 PDE is concentrated in the penile smooth muscle of the corpus cavernosum, where its normal function is to inhibit erection by degradation of cGMP, the mediator of erection. Viagra and the new drugs Cialis and Levitra all inhibit PDE-5, which is an inhibitor for corporal smooth muscle relaxation, resulting in increased blood flow in the penis in response to sexual stimulation. Comparison of Viagra, Cialis, & Levitra No head-to-head trial comparing the 3 PDE inhibitors has been performed. However, some differences between the 3 are basic: a table has been created to illustrate the major differences. An obvious proviso is that extensive data levitra vs


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levitra vs cialis Ood vessel walls levitra vs cialis, ie levitra vs cialis, vasodilation levitra vs cialis, in various organ systems. The direct intracellular mediator of the nitric oxide pathway is cGMP. PDE catalyzes the degradation of cGMP. This pathway is active in numerous organ systems levitra vs cialis, and as of this writing levitra vs cialis, a number of different PDEs are known. The various PDEs differ in their physiologic roles and tissue distribution. Type 5 PDE is concentrated in the penile smooth muscle of the corpus cavernosum levitra vs cialis, where its normal function is to inhibit erection by degradation of cGMP levitra vs cialis, the mediator of erection. Viagra and the new drugs Cialis and Levitra all inhibit PDE-5 levitra vs cialis, which is an inhibitor for corporal smooth muscle relaxation levitra vs cialis, re levitra vs cialis.

levitra vs cialis Sulting in increased blood flow in the penis in response to sexual stimulation. Comparison of Viagra levitra vs cialis, Cialis levitra vs cialis, & Levitra No head-to-head trial comparing the 3 PDE inhibitors has been performed. However levitra vs cialis, some differences between the 3 are basic: a table has been created to illustrate the major differences. An obvious proviso is that extensive data are available on Viagra (more than 20 million men treated levitra vs cialis, more than 1100 peer-reviewed articles as of Feb. & 8217;03) levitra vs cialis, but only limited data on Cialis and Levitra. Drs. Gresser and Gleiter from the U. Tubingen in Germany have compared the three drugs via literature review (Eur. J. Med. Res. 7:435 levitra vs cialis, 2002) In brief levitra vs cialis, efficacy is approximately 70% with all 3 drugs. The side effect profile is similar among the 3 drugs levitra vs cialis, except that blue discoloration of vision (overlap with PDE-6 in the retina) is seen only with Viagra (<0.5%) and muscle aches only with Cialis (~5%). Otherwise levitra vs cialis, vasodilatory side effects (headaches levitra vs cialis, nasal congestion levitra vs cialis, flushing) are common with all levitra vs cialis, but are mild levitra vs cialis, and only rarely cause men to drop out of clinical trials (2-3% quit rate). All 3 will carry a contra-indication in men using organic nitrates. Otherwise levitra vs cialis, the long half-life of Cialis (17.5 hours) is noteworthy levitra vs cialis, earning this drug the nickname & 8216;weekender levitra vs cialis, & 8217; as a single dose taken on Frida.

levitra vs cialis efficacy is approximately 70% with all 3 drugs. The side effect profile is similar among the 3 drugs levitra vs cialis, except that blue discoloration of vision (overlap with PDE-6 in the retina) is seen only with Viagra (<0.5%) and muscle aches only with Cialis (~5%). Otherwise levitra vs cialis, vasodilatory side effects (headaches levitra vs cialis, nasal congestion levitra vs cialis, flushing) are common with all levitra vs cialis, but are mild levitra vs cialis, and only rarely cause men to drop out of clinical trials (2-3% quit rate). All 3 will carry a contra-indication in men using organic nitrates. Otherwise levitra vs cialis, the long half-life of Cialis (17.5 hours) is noteworthy levitra vs cialis, earning this drug the nickname & 8216;weekender levitra vs cialis, & 8217; as a single dose taken on Friday.

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