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Acteristics and other factors differ from those that prevailed in the clinical trials. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. The cited figures, however, do provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the side effect incidence rate in the population studied. Table 1. Treatment-Emergent Adverse Events Occurring in & 179; 1% of Patients Treated With PAXIL CR in a Pool of 2 Studies in Major Depressive Disorder1,2 Body System Adverse Event % Reporting Event PAXIL CR (n = 212) Placebo (n = 211) Body as a Whole Headache 27% 20% Asthenia 14% 9% Infection3 8% 5% Abdominal Pain 7% 4% Back Pain 5% 3% Trauma4 5% 1% Pain5 3% 1% Allergic Reaction6 2% 1% Cardiovascular System Tachycardia 1% 0% Vasodilatation7 2% 0% Digestive System Nausea 22% 10% Diarrhea 18% 7% Dry Mouth 15% 8% Constipation 10% 4% Flatulence 6% 4% Decreased Appetite 4% 2% Vomiting 2% 1% Nervous System Somnolence 22% 8% Insomnia 17% 9% Dizziness 14% 4% Libido Decreased 7% 3% Tremor 7% 1% Hypertonia 3% 1% Paresthesia 3% 1% Agitation 2% 1% Confusion 1% 0% Respiratory System Yawn 5% 0% Rhinitis 4% 1% Cough Increased 2% 1% Bronchitis 1% 0% Skin and Appendages Sweating 6% 2% Photosensitivity 2% 0% Special Senses Abnormal Vision8 5% 1% Taste Perversion 2% 0% Urogenital System Abnormal Ejaculation9,10 26% 1% Female Genital Disorder9,11 10% <1% Impotence9 5% 3% Urinary Tract Infection 3% 1% Menstrual Disorder9 2% <1% Vagi