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Paxil voucher cr. Link.com The Pharmaceutical Care Network! is designed and published by RPhLink. Inc. All Rights Reserved. RPhLink.com is designed by RPhs for Pharmacists & Pharmacy Techs. For information use only! Disclaimer. RPhLink.com The Pharmaceutical Care Network! Update for Pharmacists and wholesalers regarding supply disruption of Paxil CR and Avandamet March 18, 2005 This is to alert you that Paxil CR (paroxetine hydrochloride) and Avandamet (rosiglitazone maleate metformin hydrochloride) Tablets are in extremely short supply. Shortages have resulted form the March 4, 2005, seizure action (due to manufacturing issues) by the U.S. Food and Drug Administration, currently disrupting the supply of these two products. The FDA action relates to all strengths of Paxil CR (12.5mg, 25 mg, and 37.5 mg) as well as Avandamet (1mg 500 mg, 2 mg 500 mg, 2 mg 1000 mg, 4 mg 500 mg and 4 mg 1000 mg). GlaxoSmithKline believes that the manufacturing issues do not present a health risk to patients. GSK agrees paxil voucher
 

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with the FDA that patients who use these two medicines should continue taking their tablets while supplies last. Prescribers have been advised to consider other treatment options for new patients and for patients unable to fill current prescriptions for these medications. If you are unable to fill prescriptions for these two medications, please advise patients to contact their healthcare professional about other treatment options. Because Paxil CR and the immediate-release formulation of Paxil are not bioequivalent, we cannot make any definitive recommendations about this treatment option. In terms of Avandamet, physicians may choose to transfer patients to comparable dosages and dosing regimens of Avandia ( rosiglitazone maleate) and metformin as separable tablets to ensure the equivalent daily dose is given. Please be assured that GSK is working with the FDA to resolve these issues as quickly as possible, and we will continue to keep you informed of our progress. We regret any incon paxil voucher


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paxil voucher cr Icus in patients without epilepsy. Dose may be an important predisposing factor in the development of seizures paxil voucher cr, although seizures have been reported in patients taking daily doses of GABITRIL as low as 4mg day. In most cases paxil voucher cr, patients were using concomitant medications (antidepressants paxil voucher cr, antipsychotics paxil voucher cr, stimulants paxil voucher cr, narcotics) that are thought to lower the seizure threshold. Some seizures occurred near the time of a dose increase paxil voucher cr, even after periods of prior sable dosing. The GABITRIL dosing recommendations in current labeling for treatment of epilepsy were based on use in patients with partial seizures 12 years of age and older paxil voucher cr, most of whom were taking enzym paxil voucher cr.

paxil voucher cr E-inducing antiepileptic drugs (AEDs; e.g. paxil voucher cr, carbamazepine paxil voucher cr, phenytoin paxil voucher cr, primidone paxil voucher cr, and phenobarbital) which lower plasma levels of GABITRIL by inducing its metabolism. Use of GABITRIL without enzyme-inducing antiepileptic drugs result in blood levels about twice those attained in the studies on which current dosing recommendations are based (see DOSAGE AND ADMINISTRATION). Safety and effectiveness of GABITRIL have not been established for any indication other than as adjunctive therapy for partial seizures in adults and children 12 years and older. In nonepileptic patients who develop seizures while on GABITRIL treatment paxil voucher cr, GABITRIL should be discontinued and patients should be evaluated for an underlying seizure disorder. Seizures and status epilepticus are known to occur with GABITRIL overdosage (see OVERDOSAGE). Other changes to the label can be found in the PHARMACOKINETICS paxil voucher cr, ADVERSE REACTIONS paxil voucher cr, OVERDOSAGE paxil voucher cr, and DOSAGE AND ADMINISTRATION sections of the label. GABITRIL is approved for use only as adjunctive therapy in adults and children 12 years and older in the treatment of partial seizures. Because GABITRIL has not been systematically evaluated in adequate and well-controlled clinical trials for any other indication paxil voucher cr, its safety and effectiveness have not been established for any other use. Cephalon does not reco.

paxil voucher cr Ients should be evaluated for an underlying seizure disorder. Seizures and status epilepticus are known to occur with GABITRIL overdosage (see OVERDOSAGE). Other changes to the label can be found in the PHARMACOKINETICS paxil voucher cr, ADVERSE REACTIONS paxil voucher cr, OVERDOSAGE paxil voucher cr, and DOSAGE AND ADMINISTRATION sections of the label. GABITRIL is approved for use only as adjunctive therapy in adults and children 12 years and older in the treatment of partial seizures. Because GABITRIL has not been systematically evaluated in adequate and well-controlled clinical trials for any other indication paxil voucher cr, its safety and effectiveness have not been established for any other use. Cephalon does not recom.

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