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Prozac. Names like "fluoxetine XXX", where "xxx" is the name of the laboratory. edit History Prozac was invented at Eli Lilly by a team headed by Dr. Ray W. Fuller, with Drs. Bryan B. Molloy and David T. Wong. They were later awarded the Pharmaceutical Discoverer's Award from NARSAD (National Alliance for Research on Schizophrenia and Depression) for this. 1 2 The molecule of Prozac has its origins in Diphenhydramine. In the 1960s it was found that diphenhydramine inhibits reuptake of the neurotransmitter serotonin. This discovery led to a search for viable antidepressants with similar structures and fewer side effects, culminating in the invention of fluoxetine (Prozac), a selective serotonin reuptake inhibitor (SSRI). A similar search had previously led to the synthesis of the first SSRI zimelidine from chlorpheniramine, also an antihistamine. edit FDA approval and marketing campaign Eli Lilly's Prozac was approved by the FDA on December 29, 1987 and introduced in the US at the beginning of prozac
 

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1988. The drug became very popular, with millions around the world having taken the medication. In the fall of 2001, Eli Lilly lost a patent dispute with Barr Laboratories and now fluoxetine hydrochloride is manufactured by many companies. Prozac's popularity and selling success has been aided greatly by Lilly's extensive marketing campaign for the drug, considered one of the most successful in the history of American pharmaceuticals. edit Indications edit Approved FLUOX brand Fluoxetine Prozac oral capsules Fluoxetine hydrochloride is approved in the United States to treat depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder and panic disorder. 3 In the United Kingdom, it is approved to treat depression with or without anxiety, bulimia nervosa, and obsessive-compulsive disorder. 4 In December 2003 the Food and Drug Administration (FDA) approved Symbyax to treat bipolar depression. Symbyax is a combination of fluoxetine and olanzapine. (However, t prozac


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prozac Ata Formula C17H18NF3O& 160; Mol. weight 309.3 (345.8 for •HCl) Pharmacokinetic data Bioavailability 72% peak at 6-8 hours Protein binding 94.5% Metabolism Hepatic Half life 1-3 days (acute); 4-6 days (chronic); Active metabolite Norfluoxetine 4-16 days (acute and chronic) Excretion Kidneys 80% prozac, Intestines 15% Therapeutic considerations Licence data EU& 160;US Pregnancy cat. C(US) Legal status ℞ Prescription only Routes oral Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression prozac, body dysmorphic disorder prozac, obsessive-compulsive disorder prozac, bulimia nervosa prozac, premenstrual dysphoric disorder prozac, hypochondriasis and panic di prozac.

prozac Sorder. Fluoxetine was derived from an antihistamine found to inhibit reuptake of the neurotransmitter serotonin. Compared to other popular selective serotonin reuptake inhibitors (SSRIs) prozac, fluoxetine has a strong energizing effect. This makes fluoxetine highly effective in treatment of clinical depression cases where symptoms like depressed mood and lack of energy prevail. Although stimulating prozac, it is also approved for a variety of anxiety disorders prozac, including panic disorder and obsessive compulsive disorder. Contents 1 Trade Names 2 History 3 FDA approval and marketing campaign 4 Indications 4.1 Approved 4.2 Unapproved Off-label Investigational 5 Mechanism of action 6 Atypical SSRI 7 Interactions 8 Side effects 9 Metabolism 10 Formulations 11 Controversy 12 Prozac for children 13 References 14 See also 15 External links edit Trade Names Fluoxetine is sold under the brand names Prozac prozac, Symbyax (compounded with olanzapine) prozac, Sarafem prozac, FLUX (Pakistan) prozac, Fontex (Sweden prozac, Norway) prozac, Foxetin (Argentina) prozac, Prozen (Brazil) prozac, Ladose (Greece) prozac, Fluctin (Austria prozac, Germany) prozac, Prodep (India) prozac, Fludac* (India) Oxetin (Bosnalijek prozac, Bosnia and Herzegovina) prozac, Seronil (Finland) prozac, Lovan (Australia) prozac, Prizma (Israel) and Lorien (South Africa). It is also available under many generic names like "fluoxetine XXX" prozac, where "xxx" is the name of the labora.

prozac action 6 Atypical SSRI 7 Interactions 8 Side effects 9 Metabolism 10 Formulations 11 Controversy 12 Prozac for children 13 References 14 See also 15 External links edit Trade Names Fluoxetine is sold under the brand names Prozac prozac, Symbyax (compounded with olanzapine) prozac, Sarafem prozac, FLUX (Pakistan) prozac, Fontex (Sweden prozac, Norway) prozac, Foxetin (Argentina) prozac, Prozen (Brazil) prozac, Ladose (Greece) prozac, Fluctin (Austria prozac, Germany) prozac, Prodep (India) prozac, Fludac* (India) Oxetin (Bosnalijek prozac, Bosnia and Herzegovina) prozac, Seronil (Finland) prozac, Lovan (Australia) prozac, Prizma (Israel) and Lorien (South Africa). It is also available under many generic names like "fluoxetine XXX" prozac, where "xxx" is the name of the laborat.

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Ave revealed a greater risk of adverse events representing suicidal thinking or behavior (suicidality) during the first few months of treatment in those receiving antidepressants. The average risk of such events in patients receiving antidepressants was 4%, twice the placebo risk of 2%. No suicides occurred in these trials. Patient Information From eMedicine Health & 8226; Learn about Depression at eMedicineHealth.com From WebMD & 8226; Prozac is sometimes used to treat social anxiety disorder. Find additional health information on social anxiety disorder including other treatment options at WebMD.com. DESCRIPTION Prozac& 210; (fluoxetine hydrochloride) is a psychotropic drug for oral administration. It is also marketed for the treatment of premenstrual dysphoric disorder (Sarafem& 210; , fluoxetine hydrochloride). It is designated (& 177;)-N-methyl-3-phenyl-3- (a,a,a-trifluoro-p- tolyl)oxy propylamine hydrochloride and has the empirical formula of C17H18F3NO& 183;HCl. Its molecular weight is 345.79. The structural formula is: Fluoxetine hydrochloride is a white to off-white crystalline solid with a solubility of 14 mg mL in water. Each Pulvule& 210; contains fluoxetine hydrochloride equivalent to 10 mg (32.3 mmol), 20 mg (64.7 mmol), or 40 mg (129.3 mmol) of fluoxetine. The Pulvules also contain starch, gelatin, silicone, titanium dioxide, iron oxide, and other inactive ingredients. The 10- and 20-mg Pulvules also contain FD&C Blue No. 1, and the 40-mg Pulvule also contains FD&C Blue No. 1 and FD&C Yellow No. 6. Each tablet contains fluoxetine hydrochloride equ

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