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Valium. Hem 3016 DrugBank APRD00642 Chemical data Formula C16H13N2ClO& 160; Mol. weight 284.7 g mol Pharmacokinetic data Bioavailability 93% Metabolism Hepatic Half life 20-100 hours Excretion Renal Therapeutic considerations Pregnancy cat. C(AU) D(US) Legal status Schedule IV (International) Schedule IV (CA) Routes Oral, IM, IV, suppository Diazepam (IPA: daɪˈæzɪpæm ), marketed under brand names Valium, Stesolid, Diazemuls, Seduxen, Bosaurin, Diapam, Antenex and Apozepam) 1 is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, skeletal muscle relaxant and amnestic properties. This makes it a useful drug for treating anxiety, insomnia, seizures, alcohol withdrawal, and muscle spasms. It is also used before certain medical procedures (such as endoscopies) to reduce tension and anxiety, and in some surgical procedures to induce amnesia. 2 3 Diazepam is a core medicine in the World Health Organization's "Essential Drugs List", which is a list of m valium
 

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Inimum medical needs for a basic health care system. 4 Diazepam is used to treat a wide range of conditions and is one of the most frequently prescribed benzodiazepines. Contents 1 Benzodiazepine 2 History 3 Pharmacokinetics 4 Indications 4.1 Veterinary uses 5 Dosage 5.1 Adult dosage recommendations 5.2 Pediatric dosage recommendations 5.3 Availability 6 Side effects 7 Interactions 8 Contraindications 8.1 Special caution needed 8.2 Patients at a high risk for abuse and dependence 9 Overdose 10 Recreational use 11 Popular culture references 12 Legal status 13 Physical properties 14 External links 15 References 16 Footnotes edit Benzodiazepine Diazepam is a benzodiazepine that binds to a specific subunit on the GABAA receptor at a site that is distinct from the endogenous GABA molecule. 5 6 The GABAA receptor is an inhibitory channel which, when activated, decreases neurologic activity. Due to the role of diazepam as a positive allosteric modulator of GABA, when it binds to benzodiazepin valium


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valium of other depressants (such as alcohol or other sedatives). 9 Diazepam was the top-selling pharmaceutical in the United States from 1969 to 1982 valium, with peak sales in 1978 of 2.3 billion pills. 8 In 1966 valium, The Rolling Stones released the song "Mother's Little Helper" valium, which is about a mother needing the "little yellow pill" to get through the day. 10 Over the years valium, physicians valium, psychiatrists and neurologists have discovered many new off-label uses for diazepam valium, such as treatment of spastic paresis and palliative treatment of stiff-person syndrome. 11 Diazepam is also found in nature. Several plants valium, such as potato and wheat valium, contain trace amounts of naturally o valium.

valium Ccurring diazepam and other benzodiazepines. 12 edit Pharmacokinetics Diazepam can be administered orally valium, intravenously valium, intramuscularly valium, or as a suppository. 13 When diazepam is administered orally valium, it is rapidly absorbed and has a fast onset of action. The onset of action is 1-5 minutes for IV administration and 15-30 minutes for IM administration. The duration of the diazepam's main pharmacological effects is 15 minutes to 1 hour for both routes of administration. 14 Peak plasma levels are achieved 30 minutes to 2 hours after oral administration. When diazepam is administered as an intramuscular injection valium, absorption is slow valium, erratic and incomplete. 1 15 Diazepam is highly lipid-soluble valium, and is widely distributed throughout the body after administration. It easily crosses both the blood-brain barrier and the placenta valium, and is excreted into breast milk. After absorption valium, diazepam is redistributed into muscle and adipose tissue. Continual daily doses of diazepam will quickly build up to a high concentration in the body (mainly in adipose tissue) valium, which will be far in excess of the actual dose for any given day. 13 15 Diazepam is metabolised in the liver via the cytochrome P450 enzyme system. It has a biphasic half-life of 1-2 and 2-5 days valium, and has several pharmacologically active metabolites. The main active me.

valium Diazepam is highly lipid-soluble valium, and is widely distributed throughout the body after administration. It easily crosses both the blood-brain barrier and the placenta valium, and is excreted into breast milk. After absorption valium, diazepam is redistributed into muscle and adipose tissue. Continual daily doses of diazepam will quickly build up to a high concentration in the body (mainly in adipose tissue) valium, which will be far in excess of the actual dose for any given day. 13 15 Diazepam is metabolised in the liver via the cytochrome P450 enzyme system. It has a biphasic half-life of 1-2 and 2-5 days valium, and has several pharmacologically active metabolites. The main active met.

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