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Viagra. Tion & 160;? Therapeutic considerations Pregnancy cat. N A Legal status Rx only POM Routes Oral Sildenafil citrate, sold under the names Viagra, Revatio and generically under various other names, is a drug used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH), developed by the pharmaceutical company Pfizer. Viagra pills are blue and diamond-shaped with the words "Pfizer" on one side, and "VGR xx" (where xx stands for "25", "50" or "100", the dose of that pill in milligrams) on the other. Its primary competitors on the market are tadalafil (Cialis), and vardenafil (Levitra). Contents 1 History 2 Mechanism of action 3 Dosage and price 4 Contraindications 5 Side effects 6 Other uses 6.1 Pulmonary hypertension 6.2 Raynaud's phenomenon 7 Drug abuses 7.1 Aphrodisiac 7.2 Recreational use 8 Chemical Synthesis 9 See also 10 Notes 11 External links edit History Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at viagra

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Pfizer's Sandwich, Kent research facility. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. 1 2 Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year. 3 It soon became a great success: annual sales of Viagra in the period 1999–2001 exceeded $1 billion. The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim which Pfizer disputes. 4 Their names are on the manufacturing patent application drug, but Pfize viagra

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viagra Zusman RM (1999). "ACC AHA expert consensus document. Use of sildenafil (Viagra) in patients with cardiovascular disease. American College of Cardiology American Heart Association". Journal of the American College of Cardiology 33 (1): 273-82. PMID 9935041. ^ Alert for Healthcare Professionals: Sildenafil citrate (marketed as Viagra) (07 2005) ^ Pomeranz HD viagra, Bhavsar AR. "Nonarteritic ischemic optic neuropathy developing soon after use of sildenafil (viagra): a report of seven new cases." J Neuroophthalmol. 2005 Mar;25(1):9-13. PMID 15756125. ^ Egan R viagra, Pomeranz H. "Sildenafil (Viagra) associated anterior ischemic optic neuropathy." Arch Ophthalmol. 2000 Feb; viagra.

viagra 118(2):291-2. PMID 10676804. ^ Pomeranz HD viagra, Smith KH viagra, Hart WM Jr viagra, Egan RA. "Sildenafil-associated nonarteritic anterior ischemic optic neuropathy." Ophthalmology. 2002 Mar;109(3):584-7. PMID 11874765. ^ Cunningham AV viagra, Smith KH. "Anterior ischemic optic neuropathy associated with viagra." J Neuroophthalmol. 2001 Mar;21(1):22-5. PMID 11315976. ^ Boshier A viagra, Pambakian N viagra, Shakir SA. "A case of nonarteritic ischemic optic neuropathy (NAION) in a male patient taking sildenafil." Int J Clin Pharmacol Ther. 2002 Sep;40(9):422-3. PMID 12358159. ^ Akash R viagra, Hrishikesh D viagra, Amith P viagra, Sabah S. "Case report: association of combined nonarteritic anterior ischemic optic neuropathy (NAION) and obstruction of cilioretinal artery with overdose of Viagra." J Ocul Pharmacol Ther. 2005 Aug;21(4):315-7. PMID 16117695. ^ Kloner RA. Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions. Am J Cardiol 2005;96(12B):42M-46M. PMID 16387566. ^ Pfizer viagra, Inc. (June 6 viagra, 2005). FDA Approves Pfizer's Revatio as Treatment for Pulmonary Arterial Hypertension. 2005 News Releases. Pfizer. Retrieved on December 27 viagra, 2005. ^ Fries viagra, Roland; Kaveh Shariat viagra, Hubertus von Wilmowsky viagra, and Michael Böhm (November 8 viagra, 2005). "Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory thera.

viagra Hy (NAION) and obstruction of cilioretinal artery with overdose of Viagra." J Ocul Pharmacol Ther. 2005 Aug;21(4):315-7. PMID 16117695. ^ Kloner RA. Pharmacology and drug interaction effects of the phosphodiesterase 5 inhibitors: focus on alpha-blocker interactions. Am J Cardiol 2005;96(12B):42M-46M. PMID 16387566. ^ Pfizer viagra, Inc. (June 6 viagra, 2005). FDA Approves Pfizer's Revatio as Treatment for Pulmonary Arterial Hypertension. 2005 News Releases. Pfizer. Retrieved on December 27 viagra, 2005. ^ Fries viagra, Roland; Kaveh Shariat viagra, Hubertus von Wilmowsky viagra, and Michael Böhm (November 8 viagra, 2005). "Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therap.

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