E is variability among antidepressants in the extent of clinically important inhibition of the drug metabolising isoenzyme CYP 2D6 and, in formal interaction studies, chronic dosing with sertraline 50 mg daily showed minimal elevation of steady state desipramine plasma levels (a marker of CYP 2D6 isoenzyme activity) Medicines metabolised by other CYP enzymes - In vivo interaction studies have demonstrated that chronic administration of Zoloft 200 mg daily does not inhibit the CYP 3A3 4 mediated 6-beta hydroxylation of endogenous cortisol or the metabolism of carbamazepine or terfenadine. The apparent lack of clinically significant effects of the chronic administration of Zoloft 200 mg daily on plasma concentrations of tolbutamide, phenytoin and warfarin suggests that Zoloft is not a clinically relevant inhibitor of CYP 2C9. The apparent lack of clinically significant effects of the chronic administration of Zoloft 200 mg daily on plasma concentrations of diazepam suggests that Zoloft is not a clinically relevant inhibitor of CYP 2C19. In vitro studies indicate that Zoloft has little or no potential to inhibit CYP 1A2. KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT On the evidence available, Zoloft has a wide margin of safety in overdose. Serious sequelae have not been reported following overdoses of sertraline alone of up to 6 g. Although there have been no deaths reported when Zoloft was taken alone, deaths involving overdoses of Zoloft in combination with other medicines and or alcohol have been reported. Therefore, any overdosage should be treated aggressi
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Zoloft 50mg ublic -//W3C//DTD HTML 4.01//EN http://www.w3 /TR/html4/strict.dtd>
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Zoloft 50mg ublic -//W3C//DTD HTML 4.01//EN http://www.w3 /TR/html4/strict.dtd>
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