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Zoloft. Ye pain, xerophthalmia. Rare: Abnormal lacrimation, photophobia, visual field defect. Urinary System Disorders: Infrequent: Dysuria, face edema, nocturia, polyuria, urinary incontinence. Rare: Oliguria, renal pain, urinary retention. Laboratory Tests: In man, asymptomatic elevations in serum hepatic transaminases AST (SGOT) and ALT (SGPT) to a value >=3 times the upper limit of normal have been reported infrequently (approximately 0.6% and 1.1%, respectively) in association with sertraline administration. The proportion of patients having these elevations was greater in the sertraline group than in the placebo group. These hepatic enzyme elevations usually occurred within the first 1 to 9 weeks of drug treatment and promptly diminished upon drug discontinuation. Sertraline therapy was associated with small mean increases in total cholesterol (approximately 3%) and triglycerides (approximately 5%), and a small mean decrease in serum uric acid (approximately 7%) of no apparent clinica zoloft

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L importance. to top Overdose Symptoms and Treatment: Human Experience: There have been 3 cases of sertraline overdosage (approximately 4 to 10 times the maximum recommended daily dose). These 3 patients recovered completely without the need for specific therapy. Management of Overdoses: Establish and maintain an airway, insure adequate oxygenation and ventilation. Activated charcoal, which may be used with sorbitol, may be as or more effective than emesis or lavage, and should be considered in treating overdose. Cardiac and vital signs monitoring are recommended along with general symptomatic and supportive measures. There are no specific antidotes for sertraline. Due to the large volume of distribution of sertraline, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit. In managing overdose, the possibility of multiple drug involvement must be considered. to top Dosage The administration should be initiated at 50 mg daily and increased grad zoloft

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zoloft Edema zoloft, periorbital edema zoloft, peripheral edema zoloft, peripheral ischemia zoloft, syncope zoloft, tachycardia. Rare: Precordial chest pain zoloft, substernal chest pain zoloft, aggravated hypertension zoloft, myocardial infarction zoloft, varicose veins. Central and Peripheral Nervous System Disorders: Frequent: Confusion. Infrequent: Ataxia zoloft, abnormal coordination zoloft, abnormal gait zoloft, hyperesthesia zoloft, hyperkinesia zoloft, hypokinesia zoloft, migraine zoloft, nystagmus zoloft, vertigo. Rare: Local anesthesia zoloft, coma zoloft, convulsions zoloft, dyskinesia zoloft, dysphonia zoloft, hyporeflexia zoloft, hypotonia zoloft, ptosis. Disorders of Skin and Appendages: Infrequent: Acne zoloft, alopecia zoloft, pruritus zoloft, erythematous rash zoloft, maculopapular rash zoloft, dry skin. Rare: Bullous eruption zoloft, dermatitis zoloft, erythem zoloft.

zoloft A multiforme zoloft, abnormal hair texture zoloft, hypertrichosis zoloft, photosensitivity reaction zoloft, follicular rash zoloft, skin discoloration zoloft, abnormal skin odor zoloft, urticaria. Endocrine Disorders: Rare: Exophthalmos zoloft, gynecomastia. Gastrointestinal Disorders: Infrequent: Dysphagia zoloft, eructation. Rare: Diverticulitis zoloft, fecal incontinence zoloft, gastritis zoloft, gastroenteritis zoloft, glossitis zoloft, gum hyperplasia zoloft, hemorrhoids zoloft, hiccup zoloft, melena zoloft, hemorrhagic peptic ulcer zoloft, proctitis zoloft, stomatitis zoloft, ulcerative stomatitis zoloft, tenesmus zoloft, tongue edema zoloft, tongue ulceration. General: Frequent: Asthenia. Infrequent: Malaise zoloft, generalized edema zoloft, rigors zoloft, weight decrease zoloft, weight increase. Rare: Enlarged abdomen zoloft, halitosis zoloft, otitis media zoloft, aphthous stomatitis. Hematopoietic and Lymphatic: Infrequent: Lymphadenopathy zoloft, purpura. Rare: Anemia zoloft, anterior chamber eye hemorrhage. Metabolic and Nutritional Disorders: Rare: Dehydration zoloft, hypercholesterolemia zoloft, hypoglycemia. Musculo-Skeletal System Disorders: Infrequent: Arthralgia zoloft, arthrosis zoloft, dystonia zoloft, muscle cramps zoloft, muscle weakness. Rare: Hernia. Psychiatric Disorders: Infrequent: Abnormal dreams zoloft, aggressive reaction zoloft, amnesia zoloft, apathy zoloft, delusion zoloft, depersonalization zoloft, depression zoloft, aggravated depression zoloft, emotional lability zoloft, euphoria zoloft, hallucination zoloft, neurosis zoloft, paranoid reaction zoloft, suicide attempt (including suicidal ideation) zoloft, teeth-grinding zoloft, abnormal thinking. Ra.

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Ailure(1) 7 <1 17 2 19 1 11 1 Mouth Dry 16 9 14 9 15 10 11 6 Sweating Increased 8 3 6 1 5 1 4 2 Centr. & Periph. Nerv. System Disorders Somnolence 13 6 15 8 15 9 13 9 Tremor 11 3 8 1 5 1 5 1 Dizziness 12 7 17 9 10 10 8 5 General Fatigue 11 8 14 10 11 6 10 5 Pain 1 2 3 1 3 3 4 6 Malaise <1 1 1 1 7 14 10 10 Gastrointestinal Disorders Abdominal Pain 2 2 5 5 6 7 6 5 Anorexia 3 2 11 2 7 2 8 2 Constipation 8 6 6 4 7 3 3 3 Diarrhea Loose Stools 18 9 24 10 20 9 24 15 Dyspepsia 6 3 10 4 10 8 6 6 Nausea 26 12 30 11 29 18 21 11 Psychiatric Disorders Agitation 6 4 6 3 6 2 5 5 Insomnia 16 9 28 12 25 18 20 11 Libido Decreased 1 <1 11 2 7 1 7 2 PMDD Daily Dosing PMDD Luteal Phase Dosing(2) Body System Adverse Event ZOLOFT (N=121) Placebo (N=122) ZOLOFT (N=136) Placebo (N=127) ZOLOFT (N=344) Placebo (N=268) Autonomic Nervous System Disorders Ejaculation Failure(1) N A N A N A N A 14 - Mouth Dry 6 3 10 3 12 4 Sweating Increased 6 <1 3 0 11 2 Centr. & Periph. Nerv. System Disorders Somnolence 7 <1 2 0 9 6 Tremor 2 0 <1 <1 9 3 Dizziness 6 3 7 5 14 6 General Fatigue 16 7 10 <1 12 6 Pain 6 <1 3 2 1 3 Malaise 9 5 7 5 8 3 Gastrointestinal Disorders Abdominal Pain 7 <1 3 3 5 5 Anorexia 3 2 5 0 6 3 Constipation 2 3 1 2 5 3 Diarrhea Loose Stools 13 3 13 7 21 8 Dyspepsia 7 2 7 3 13 5 Nausea 23 9 13 3 22 8 Psychiatric Disorders Agitation 2 <1 1 0 4 2 Insomnia 17 11 12 10 25 10 Libido Decreased 11 2 4 2 9 3 (1)Primarily ejaculatory delay. Denominator used was for male patients only (N=271 ZOLOFT major depressive disorder other*; N=271 placebo major depressive disorder o

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