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Cialis levitra viagra vs. Acting to increase blood flow in the penis in response to sexual stimulation. However, there are important differences between the three, differences that could influence safety, specificity, duration of action, and ultimately, public acceptance within this class of drug. Giles Brindley and Drug Therapy for ED Modern drug therapy for ED was advanced enormously in 1983 when British physiologist Giles Brindley, Ph.D. dropped his trousers and demonstrated to a shocked AUA audience his phentolamine-induced erection. The drug Brindley injected into his penis was a non-specific vasodilator, an alpha-blocking agent, and the mechanism of action was clearly corporal smooth muscle relaxation. The effect that Brindley discovered, established the fundamentals for the later development of specific, safe, orally-effective drug therapies, ie, PDE-5 inhibitors. PDE Inhibition and Smooth Muscle Relaxation Phosphodiesterase (PDE) is an enzyme that causes breakdown of cyclic GMP, which is the direct intr cialis levitra

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Acellular mediator in the nitric oxide (nonadrenergic, noncholinergic) pathway. Discovery of this pathway led to a Nobel Prize in 1998 for the scientists responsible. The nitric oxide system causes relaxation of smooth muscle in blood vessel walls, ie, vasodilation, in various organ systems. The direct intracellular mediator of the nitric oxide pathway is cGMP. PDE catalyzes the degradation of cGMP. This pathway is active in numerous organ systems, and as of this writing, a number of different PDEs are known. The various PDEs differ in their physiologic roles and tissue distribution. Type 5 PDE is concentrated in the penile smooth muscle of the corpus cavernosum, where its normal function is to inhibit erection by degradation of cGMP, the mediator of erection. Viagra and the new drugs Cialis and Levitra all inhibit PDE-5, which is an inhibitor for corporal smooth muscle relaxation, resulting in increased blood flow in the penis in response to sexual stimulation. Comparison of Viagra, C cialis levitra

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cialis levitra viagra vs Itric oxide system causes relaxation of smooth muscle in blood vessel walls cialis levitra viagra vs, ie cialis levitra viagra vs, vasodilation cialis levitra viagra vs, in various organ systems. The direct intracellular mediator of the nitric oxide pathway is cGMP. PDE catalyzes the degradation of cGMP. This pathway is active in numerous organ systems cialis levitra viagra vs, and as of this writing cialis levitra viagra vs, a number of different PDEs are known. The various PDEs differ in their physiologic roles and tissue distribution. Type 5 PDE is concentrated in the penile smooth muscle of the corpus cavernosum cialis levitra viagra vs, where its normal function is to inhibit erection by degradation of cGMP cialis levitra viagra vs, the mediator of erection. Viagra and the new drugs Cialis and Levitra all inhibit PDE-5 cialis levitra viagra vs, whic cialis levitra viagra vs.

cialis levitra viagra vs H is an inhibitor for corporal smooth muscle relaxation cialis levitra viagra vs, resulting in increased blood flow in the penis in response to sexual stimulation. Comparison of Viagra cialis levitra viagra vs, Cialis cialis levitra viagra vs, & Levitra No head-to-head trial comparing the 3 PDE inhibitors has been performed. However cialis levitra viagra vs, some differences between the 3 are basic: a table has been created to illustrate the major differences. An obvious proviso is that extensive data are available on Viagra (more than 20 million men treated cialis levitra viagra vs, more than 1100 peer-reviewed articles as of Feb. & 8217;03) cialis levitra viagra vs, but only limited data on Cialis and Levitra. Drs. Gresser and Gleiter from the U. Tubingen in Germany have compared the three drugs via literature review (Eur. J. Med. Res. 7:435 cialis levitra viagra vs, 2002) In brief cialis levitra viagra vs, efficacy is approximately 70% with all 3 drugs. The side effect profile is similar among the 3 drugs cialis levitra viagra vs, except that blue discoloration of vision (overlap with PDE-6 in the retina) is seen only with Viagra (<0.5%) and muscle aches only with Cialis (~5%). Otherwise cialis levitra viagra vs, vasodilatory side effects (headaches cialis levitra viagra vs, nasal congestion cialis levitra viagra vs, flushing) are common with all cialis levitra viagra vs, but are mild cialis levitra viagra vs, and only rarely cause men to drop out of clinical trials (2-3% quit rate). All 3 will carry a contra-indication in men using organic nitrates. Otherwise cialis levitra viagra vs, the long half-life of Cialis (17.5 hours) is noteworthy cialis levitra viagra vs, earning this drug the nickna.

cialis levitra viagra vs Literature review (Eur. J. Med. Res. 7:435 cialis levitra viagra vs, 2002) In brief cialis levitra viagra vs, efficacy is approximately 70% with all 3 drugs. The side effect profile is similar among the 3 drugs cialis levitra viagra vs, except that blue discoloration of vision (overlap with PDE-6 in the retina) is seen only with Viagra (<0.5%) and muscle aches only with Cialis (~5%). Otherwise cialis levitra viagra vs, vasodilatory side effects (headaches cialis levitra viagra vs, nasal congestion cialis levitra viagra vs, flushing) are common with all cialis levitra viagra vs, but are mild cialis levitra viagra vs, and only rarely cause men to drop out of clinical trials (2-3% quit rate). All 3 will carry a contra-indication in men using organic nitrates. Otherwise cialis levitra viagra vs, the long half-life of Cialis (17.5 hours) is noteworthy cialis levitra viagra vs, earning this drug the nicknam.

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